abstract：:During the last decades, adipogenesis has become an emerging field of study in aquaculture due to the relevance of the adipose tissue in many physiological processes and its connection with the endocrine system. In this sense, recent studies have translated into the establishment of preadipocyte culture models from se...

journal_title：Frontiers in endocrinology

authors： Salmerón C,Riera-Heredia N,Gutiérrez J,Navarro I,Capilla E

更新日期：2016-08-22 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) is a pleotropic metabolic regulator, expression of which is elevated during fasting. To this end, the precise role played by FGF21 in the biology of fasting has been the subject of several recent studies, which have demonstrated contributions to the regulation of both lipid and carb...

journal_title：Frontiers in endocrinology

authors： Antonellis PJ,Hayes MP,Adams AC

更新日期：2016-06-30 00:00:00

abstract：:The receptor tyrosine kinase superfamily comprises many cell-surface receptors including the insulin receptor (IR) and type 1 insulin-like growth factor receptor (IGF1R) that are constitutively homodimeric transmembrane glycoproteins. Therefore, these receptors require ligand-triggered domain rearrangements rather tha...

journal_title：Frontiers in endocrinology

authors： Mohammadiarani H,Vashisth H

更新日期：2016-06-20 00:00:00

abstract：:Endocannabinoids control male reproduction acting at central and local level via cannabinoid receptors. The cannabinoid receptor CB1 has been characterized in the testis, in somatic and germ cells of mammalian and non-mammalian animal models, and its activity related to Leydig cell differentiation, steroidogenesis, sp...

journal_title：Frontiers in endocrinology

authors： Cobellis G,Meccariello R,Chianese R,Chioccarelli T,Fasano S,Pierantoni R

更新日期：2016-06-03 00:00:00

abstract：:The post-translational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAc) is regulated by a unique couple of enzymes. O-GlcNAc transferase (OGT) transfers the GlcNAc residue from UDP-GlcNAc, the final product of the hexosamine biosynthetic pathway (HBP), whereas O-GlcNAcase (OGA) removes it. This st...

journal_title：Frontiers in endocrinology

authors： Steenackers A,Olivier-Van Stichelen S,Baldini SF,Dehennaut V,Toillon RA,Le Bourhis X,El Yazidi-Belkoura I,Lefebvre T

更新日期：2016-05-25 00:00:00

abstract：:In rodents, insufficient thyroid hormone (TH) gestationally has adverse effects on cerebral cortex development. Comparable studies of humans examining how TH insufficiency affects cortical morphology are limited to children with congenital hypothyroidism or offspring of hypothyroxinemic women; effects on cortex of chi...

journal_title：Frontiers in endocrinology

authors： Lischinsky JE,Skocic J,Clairman H,Rovet J

更新日期：2016-02-25 00:00:00

abstract：:Aging represents one of the most complicated and highly integrated somatic processes. Healthy aging is suggested to rely upon the coherent regulation of hormonal and neuronal communication between the central nervous system and peripheral tissues. The hypothalamus is one of the main structures in the body responsible ...

journal_title：Frontiers in endocrinology

authors： Martin B,Chadwick W,Janssens J,Premont RT,Schmalzigaug R,Becker KG,Lehrmann E,Wood WH,Zhang Y,Siddiqui S,Park SS,Cong WN,Daimon CM,Maudsley S

更新日期：2016-01-18 00:00:00

abstract：:[This corrects the article on p. 162 in vol. 6, PMID: 26528241.]. ...

journal_title：Frontiers in endocrinology

authors： Frontiers Production Office.

更新日期：2015-11-16 00:00:00

abstract：:Although G protein-coupled receptor (GPCR) internalization has long been considered as a major aspect of the desensitization process that tunes ligand responsiveness, internalization is also involved in receptor resensitization and signaling, as well as the ligand scavenging function of some atypical receptors. Intern...

journal_title：Frontiers in endocrinology

authors： Levoye A,Zwier JM,Jaracz-Ros A,Klipfel L,Cottet M,Maurel D,Bdioui S,Balabanian K,Prézeau L,Trinquet E,Durroux T,Bachelerie F

更新日期：2015-11-09 00:00:00

abstract：:Last two decades of structure-function studies performed in numerous laboratories provided substantial progress in understanding basic science, physiological, pathophysiological, pharmacological, and comparative aspects of glycoprotein hormones (GPHs) and their cognate receptors. Multiple concepts and models developed...

journal_title：Frontiers in endocrinology

authors： Szkudlinski MW

更新日期：2015-10-19 00:00:00

abstract：:The 3D arrangement of porous granular biomaterials usable to fill bone defects has received little study. Granular biomaterials occupy 3D space when packed together in a manner that creates a porosity suitable for the invasion of vascular and bone cells. Granules of beta-tricalcium phosphate (β-TCP) were prepared with...

journal_title：Frontiers in endocrinology

authors： Chappard D,Terranova L,Mallet R,Mercier P

更新日期：2015-10-12 00:00:00

abstract：:RFamide-related peptide-3 (RFRP-3) [mammalian ortholog to gonadotropin-inhibiting hormone (GnIH)] potently inhibits gonadotropin secretion in mammals. Studies of RFRP-3 immunoreactivity and Rfrp expression (the gene encoding RFRP-3) in mammalian brains have uncovered several possible pathways regulating RFRP-3 neurons...

journal_title：Frontiers in endocrinology

authors： Poling MC,Kauffman AS

更新日期：2015-09-24 00:00:00

abstract：:The human lutropin (hLH)/choriogonadotropin (hCG) receptor (LHCGR) can be activated by binding two slightly different gonadotropic glycoprotein hormones, choriogonadotropin (CG) - secreted by the placenta, and lutropin (LH) - produced by the pituitary. They induce different signaling profiles at the LHCGR. This cannot...

journal_title：Frontiers in endocrinology

authors： Grzesik P,Kreuchwig A,Rutz C,Furkert J,Wiesner B,Schuelein R,Kleinau G,Gromoll J,Krause G

更新日期：2015-09-22 00:00:00

abstract：:Parathyroid (PTH) exploration surgery carries the risk of developing post-operative thyroiditis due to vigorous manual manipulation of the thyroid gland during surgery. Post-operative thyroiditis has a wide spectrum of clinical manifestations. However, it remains underreported. Here, we describe a case of post-operati...

journal_title：Frontiers in endocrinology

authors： Hakami YA

更新日期：2015-08-18 00:00:00

abstract：:The relaxin-like RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/tumor necrosis factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor, RXFP1, with functions in brain cancer....

journal_title：Frontiers in endocrinology

authors： Thanasupawat T,Glogowska A,Burg M,Wong GW,Hoang-Vu C,Hombach-Klonisch S,Klonisch T

更新日期：2015-08-13 00:00:00

abstract：:In addition to the obvious differences in body shape, there are substantial differences in lipid metabolism between men and women. These differences include how dietary fatty acids are handled, the secretion and clearance of very low-density lipoprotein-triglycerides, the release rates of free fatty acids (FFA) from a...

journal_title：Frontiers in endocrinology

authors： Santosa S,Jensen MD

更新日期：2015-07-02 00:00:00

abstract：:Pituitary adenomas are common neoplasms. Their classification is based upon size, invasion of adjacent structures, sporadic or familial cases, biochemical activity, clinical manifestations, morphological characteristics, response to treatment and recurrence. Although they are considered benign tumors, some of them are...

journal_title：Frontiers in endocrinology

authors： Syro LV,Rotondo F,Ramirez A,Di Ieva A,Sav MA,Restrepo LM,Serna CA,Kovacs K

更新日期：2015-06-12 00:00:00

abstract：:This brief review describes some representative methodological approaches to the isolation of putative endogenous inhibitors of epithelial sodium transport - i.e., as ouabain-like factors (OLF) that inhibit the sodium transport enzyme Na-K-ATPase or inhibit the epithelial sodium channel (ENaC). Gel chromatography and ...

journal_title：Frontiers in endocrinology

authors： Kramer HJ

更新日期：2015-05-20 00:00:00

abstract：:The increase of life expectancy has led to the increase of age-related diseases such as osteoporosis. Osteoporosis is characterized by bone weakening promoting the occurrence of fractures with defective bone regeneration. Men aged over 50 have a prevalence for osteoporosis of 20%, which is related to a decline in sex ...

journal_title：Frontiers in endocrinology

authors： Beranger GE,Djedaini M,Battaglia S,Roux CH,Scheideler M,Heymann D,Amri EZ,Pisani DF

更新日期：2015-05-19 00:00:00

abstract：:The p53-related gene p63 is required for epithelial cell establishment and its expression is often altered in tumor cells. Great strides have been made in understanding the pathways and mechanisms that regulate p63 levels, such as the Wnt, Hedgehog, Notch, and EGFR pathways. We discuss here the multiple signaling path...

journal_title：Frontiers in endocrinology

authors： Yoh K,Prywes R

更新日期：2015-04-28 00:00:00

abstract：:The brain is composed of neurons and non-neuronal cells, with the latter encompassing glial, ependymal and endothelial cells, as well as pericytes and progenitor cells. Studies aimed at understanding how the brain operates have traditionally focused on neurons, but the importance of non-neuronal cells has become incre...

journal_title：Frontiers in endocrinology

authors： Argente-Arizón P,Freire-Regatillo A,Argente J,Chowen JA

更新日期：2015-03-26 00:00:00

abstract：:The insulin/IGF system plays an important role in cancer progression. Accordingly, elevated levels of circulating insulin have been associated with an increased cancer risk as well as with aggressive and metastatic cancer phenotypes. Numerous studies have documented that estrogens cooperate with the insulin/IGF system...

journal_title：Frontiers in endocrinology

authors： De Marco P,Cirillo F,Vivacqua A,Malaguarnera R,Belfiore A,Maggiolini M

更新日期：2015-03-06 00:00:00

abstract：:Most of the described structures of podocytes in health and disease have been inferred from light and electron microscopic studies of rodent models. The variation in filtration barrier features is measured on micrographs, the aim being statistical significance. This is the technical campaign waged against kidney disea...

journal_title：Frontiers in endocrinology

authors： Neal CR

更新日期：2015-02-23 00:00:00

abstract：:The estrogen receptor and glucocorticoid receptor are members of the nuclear receptor superfamily that can signal using both non-genomic and genomic transcriptional modes. Though genomic modes of signaling have been well characterized and several behaviors attributed to this signaling mechanism, the physiological sign...

journal_title：Frontiers in endocrinology

authors： Rainville J,Pollard K,Vasudevan N

更新日期：2015-02-16 00:00:00

abstract：:Successful discontinuation of cabergoline (CAB) treatment has been reported in 31-75% of prolactinomas patients treated for at least 2 years. In contrast, it is not well established whether CAB therapy can be successfully withdrawn after a failed first attempt. This prospective open trial was designed to address this ...

journal_title：Frontiers in endocrinology

authors： Vilar L,Albuquerque JL,Gadelha PS,Rangel Filho F,Siqueira AM,da Fonseca MM,Viana KF,Gomes BS,Lyra R

更新日期：2015-02-04 00:00:00

abstract：:After decades of primarily morphological study, positional cloning of the NPHS1 gene was the landmark event that established aberrant podocyte genetics as a pivotal cause of malfunction of the glomerular filter. This ended any uncertainty whether genetic mutation plays a significant role in hereditary nephrotic syndro...

journal_title：Frontiers in endocrinology

authors： Bierzynska A,Soderquest K,Koziell A

更新日期：2015-01-23 00:00:00

abstract：:Prostate cancer (PCa) is the major cause of cancer-related death among the male population of Western society, and androgen-deprivation therapy (ADT) represents the first line in PCa treatment. However, although androgen receptor (AR) expression is maintained throughout the various stages of PCa, ADT frequently fails....

journal_title：Frontiers in endocrinology

authors： Di Donato M,Giovannelli P,Cernera G,Di Santi A,Marino I,Bilancio A,Galasso G,Auricchio F,Migliaccio A,Castoria G

更新日期：2015-01-19 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver diseases closely associated with obesity and insulin resistance; deficient growth hormone (GH) action in liver has been implicated as a mechanism. Here, we investigated the evolution of NAFLD in aged mice with liver-sp...

journal_title：Frontiers in endocrinology

authors： Fan Y,Fang X,Tajima A,Geng X,Ranganathan S,Dong H,Trucco M,Sperling MA

更新日期：2014-12-18 00:00:00

abstract：:Natriuretic hormones (NH) include three groups of compounds: the natriuretic peptides (ANP, BNP and CNP), the gastrointestinal peptides (guanylin and uroguanylin), and endogenous cardiac steroids. These substances induce the kidney to excrete sodium and therefore participate in the regulation of sodium and water homeo...

journal_title：Frontiers in endocrinology

authors： Hodes A,Lichtstein D

更新日期：2014-11-28 00:00:00

abstract：:The paper reviews the early stages of the research on natriuretic hormone. The described experimental work was designed and accomplished in several internationally recognized laboratories where the author was invited to extend his projects. The cross-circulation experiments in animals with acutely increased extracellu...

journal_title：Frontiers in endocrinology

authors： Lichardus B

更新日期：2014-11-11 00:00:00

abstract：:Transient activation of the hypothalamic-pituitary-gonadal axis in early infancy plays an important role in male genital development and sexual differentiation of the brain, but factors contributing to individual variation in testosterone levels during this period are poorly understood. We measured salivary testostero...

journal_title：Frontiers in endocrinology

authors： Xia K,Yu Y,Ahn M,Zhu H,Zou F,Gilmore JH,Knickmeyer RC

更新日期：2014-10-30 00:00:00

abstract：:Progression and severity of type 1 diabetes is dependent upon inflammatory induction of nitric oxide production and consequent pancreatic β-cell damage. Glucocorticoids (GCs) are highly effective anti-inflammatory agents but have been precluded in type 1 diabetes and in islet transplantation protocols because they exa...

journal_title：Frontiers in endocrinology

authors： Liu X,Turban S,Carter RN,Ahmad S,Ramage L,Webster SP,Walker BR,Seckl JR,Morton NM

更新日期：2014-10-14 00:00:00

abstract：:In the developed world, the hazards associated with obesity have largely outstripped the risk of starvation. Obesity remains a difficult public health issue to address, due in large part to the many disciplines involved. A full understanding requires knowledge in the fields of genetics, endocrinology, psychology, soci...

journal_title：Frontiers in endocrinology

authors： Neymotin F,Nemzer LR

更新日期：2014-10-07 00:00:00

abstract：:The oncogene-induced senescence is emerging as a potent tumor suppressor mechanism and as a possible therapeutic target. Macroautophagy is intimately linked to the senescence condition setup, although its role has not been elucidated yet. Here, we discuss up-to-date concepts of senescence-related macroautophagy and ev...

journal_title：Frontiers in endocrinology

authors： Grasso D,Vaccaro MI

更新日期：2014-09-29 00:00:00

abstract：:The incidence of type 2 diabetes significantly increases with age. The relevance of this association is dramatically magnified by the concomitant global aging of the population, but the underlying mechanisms remain to be fully elucidated. Here, some recent advances in this field are reviewed at the level of both the p...

journal_title：Frontiers in endocrinology

authors： De Tata V

更新日期：2014-09-03 00:00:00

abstract：:The orexigenic peptide hormone ghrelin is synthesized in the stomach and its receptor growth hormone secretagogue receptor (GHSR1a) is expressed mainly in the central nervous system (CNS). In this review, we confine our discussion to the physiological role of GHSR1a in the brain. Paradoxically, despite broad expressio...

journal_title：Frontiers in endocrinology

authors： Kern A,Grande C,Smith RG

更新日期：2014-08-18 00:00:00

abstract：:The extracellular signal-regulated kinases (ERKs) are key components of multiple important cell signaling pathways regulating diverse biological responses. This signaling is characterized by phosphorylation cascades leading to ERK1/2 activation and promoted by various cell surface receptors including G protein-coupled...

journal_title：Frontiers in endocrinology

authors： Ayoub MA,Trebaux J,Vallaghe J,Charrier-Savournin F,Al-Hosaini K,Gonzalez Moya A,Pin JP,Pfleger KD,Trinquet E

更新日期：2014-06-23 00:00:00

abstract：:It has been generally assumed that insulin circulates freely in blood. However it can also interact with plasma proteins. Insulin receptors are located in the membrane of target cells and consist of an alpha and beta subunits with a tyrosine kinase cytoplasmic domain. The ectodomain, called soluble insulin receptor (S...

journal_title：Frontiers in endocrinology

authors： Hiriart M,Sanchez-Soto C,Diaz-Garcia CM,Castanares DT,Avitia M,Velasco M,Mas-Oliva J,Macias-Silva M,González-Villalpando C,Delgado-Coello B,Sosa-Garrocho M,Vidaltamayo R,Fuentes-Silva D

更新日期：2014-06-19 00:00:00

abstract：:Estetrol (E4) is a natural human estrogen present at high concentrations during pregnancy. Due to its high oral bioavailability and long plasma half-life, E4 is particularly suitable for therapeutic applications. E4 acts as a selective estrogen receptor (ER) modulator, exerting estrogenic actions on the endometrium or...

journal_title：Frontiers in endocrinology

authors： Giretti MS,Montt Guevara MM,Cecchi E,Mannella P,Palla G,Spina S,Bernacchi G,Di Bello S,Genazzani AR,Genazzani AD,Simoncini T

更新日期：2014-05-26 00:00:00

abstract：:Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, which then modulates the degree of adaptation and response to a later stressor. It is known that early-life stress can impact on later health but less is known about how early-life stress impairs HPA axis activity, contributing to maladaptation of the str...

journal_title：Frontiers in endocrinology

authors： Maniam J,Antoniadis C,Morris MJ

更新日期：2014-05-13 00:00:00